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The robust DNA repair and self-renewing capabilities of glioblastoma cells and glioma initiating cells (GICs), resp., promote resistance against all current treatment modalities
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10.1111/j.0954-6820.1968.tb02452.x [DOI] [PubMed] 51.Chapman LE, Darling AL, Brown JE (2016) Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: a systematic review and meta-analysis
It remains in clinical trials globally, with Phase 3 studies ongoing
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