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It uses l-arginine as a substrate and needs tetrahydrobiopterin (BH4) as a cofactor

The activation of estrogen receptor leads to increased expression of cyclins, and prompts cancer cells to transition from the quiescent phase to the proliferative phase 31 , leading to tumor growth and development

This information is necessary to determine whether the formation of the biotransformation product requires any microbial enzymes

10.1109/JBHI.2019.2891779 111 XiaoZ.YangZ.XuM

Direct contact between the peptide and esophageal tissue during swallowing provides local exposure in addition to systemic effects achieved after absorption