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Description
All except one case were carriers of the same mutation, S467C.18 This is change of Serine to Cysteine at codon 467
10.4049/jimmunol.179.9.6097 45 CholoM
The EET are primarily anti-inflammatory and their metabolism by sEH results in the generation of molecules (dihydroxyeicosatrienoic acids) that have reduced activity or can even be pro-inflammatory
In rare cases, serious side effects such as allergic reactions, rapid heartbeat, and chest pain have been reported
[DOI] [PubMed] [Google Scholar] 87.von Bohlen und Halbach O., Klausch M
