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These obstructions made of keratin, cellular debris, granulation tissue, and/or fibrosis can increase stress, contribute to progression of disease, result in lid tenderness, inflammation, recurrent eyelid infections (styes, hordeola, chalazia, cellulitis), and other symptoms of ocular irritation, and can exist simultaneously with traditional MGD

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This combination contributes to improved glucose control and weight loss

When cells contain fat stores, such as differentiated 3T3-L1 cells (145) as well as HeLa cells grown in oleic acidrich medium (115), desnutrin/ATGL is found both in the cytoplasm and tightly associated with the lipid droplet (115, 130, 145)