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Effects of IGF-1 in physiological conditions The classical view of IGF-1 as an essential growth factor is expanded by findings of its significant metabolic effects whereby IGF-1 stimulation of its receptor serves as a signal that notifies cells about the availability of adequate nutrients, thus coordinating protein, fat, and carbohydrate metabolism in various cell types

Therefore, the development of drugs or therapies targeting iron metabolism could become a significant direction in lung cancer treatment, warranting further attention from clinical researchers and drug developers

Jabbour EJ, Kantarjian HM, Cameron Y, Ravandi F, Cortes JE, Garcia-Manero G, Ghanem H, Kadia TM, Faderl S, O'Brien S, Mathisen MS, Brandt M, Pemmaraju N, Thomas DA, Bass J, Borthakur G

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Reduced levels of mitochondrial proteins such as NADH-ubiquinol oxidoreductase (NDUFB8) and voltage-dependent anion channel (VDAC) were observed in the affected white matter of patients with X-ALD (88), suggesting that mitochondrial content or function is impaired in X-ALD