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Based on this finding, we predict that these reduced doses may still provide adequate therapeutic coverage while mitigating the risk of excessive systemic exposure under DDI conditions

EAAT2 is predominantly expressed in astrocytes

doi: 10.1016/j.cmet.2021.02.015 65 TangDKroemerGKangR

Surprisingly, we observed an increase in expression and the entire zF was positive for both enzymes