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Moreover, ALC and NAC mitigate Nf-kB overactivated signal, attenuating NLRP3 inflammasome pathway (IL1 and IL18) and decreasing serum TNF-alpha, IL-1, IL-6 levels, and PCR [161, 202, 217], thereby their immunomodulatory activities [161, 227, 228], and protecting against cytokine storms [82, 135, 218]

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In addition to cytoprotection, Nrf2 also controls genes involved in intermediary metabolism, positively regulating those involved in NADPH generation, purine biosynthesis, and the -oxidation of fatty acids, while suppressing those involved in lipogenesis and gluconeogenesis