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For patients avoiding fish, algae and flaxseed are also good vegan alternatives. She adds that omega-3s offer two additional benefits: enhancing isotretinoin absorption and helping to lower triglyceride levels

Fish is rich in TMAO, a randomized controlled trial in young men showed that fish yields higher circulating and urinary concentrations of TMAO, TMA, and DMA than eggs, beef, or fruit control (Taesuwan et al., 2017)

Trimethylamine-N-Oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism

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The homozygous individuals for the CYP1A2 *1A/*1A genotype are fast caffeine metabolizers, while homozygous carriers of the e*1F allele (or the C polymorphism) are slow caffeine metabolizers, resulting in longer caffeine exposure [77]