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2) acts as a nonselective agonist of sphingosine-1-phosphate receptors (S1P1R, S1P3R, S1P4R, and S1P5R but not S1P2R)

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Specifically, while one study did not find a significant difference in GSSG levels in old relative to young adults (Yang et al., 1995), a second study reported increasing levels of GSSG (linear relationship) from 45 yrs of age (Jones et al., 2002)