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Nat Med (2004) 10(Suppl 7):S1825

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Although the precise etiology of the AD remains unclear, but its pathology is mainly defined by two hallmarks: The extracellular neurotoxic senile plaques composed of amyloid- (A) peptides, which are generated from the proteolytic cleavage of amyloid precursor protein (APP) by -site APP-cleaving enzyme-1 (BACE-1), and intracellular neurofibrillary tangles that are composed of tau protein filaments