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10.1002/ptr.6178 164 PatelD.ShuklaS.GuptaS

p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia

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Matrine was proven to inhibit SRC activity by non-competitively blocking the autophosphorylation of Tyr419 within the SRC domain, thereby inhibiting downstream phosphorylation levels of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 (MAPK/ERK), Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3), and PI3K/Akt signaling in cancer cells [222]

Rare but Serious Side Effects: Allergic reactions, such as rash, swelling, or difficulty breathing