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[PubMed] [Google Scholar] 193.Farrell N, Ha TTB, Souchard JP, Wimmer FL, Cros S, Johnson NP

This fibrosis stiffens the heart muscle, reducing its ability to contract and relax effectively, further impairing cardiac function [89]

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During the progression of OA, abnormal remodeling of subchondral bone increases mineral density resulting in sclerosis and severe cartilage degradation [185]
