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The activation of insulin-like growth factor receptor (IGF1R) results in phosphorylation and activation of PI3K and AKT

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2017;6:E112

doi: 10.3389/fcell.2020.00479 306 PizzinoGIrreraNCucinottaMPallioGManninoFArcoraciVet al

The proximal TCR signaling machinery, including zeta chain-associated protein kinase 70, linker of activated T cell, SH2 domain-containing leukocyte protein, phospholipase C1, and protein kinase C, is involved in driving ROS production upon T cell activation (36, 41, 43)