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A recent study reported that parietal WMH pathogenesis in AD is related to axonal loss, through Wallerian-like degeneration, which corresponds to cortical phosphorylated tau burden, and demyelination in patients with AD but to vasculopathy and ischemia (by sclerotic index as a marker of small vessel disease and myelin associated glycoprotein to proteolipid protein ratio as a measure of hypoperfusion) in individuals without AD, suggesting that some degree of WMH is secondary to neurodegeneration in the context of AD [57]

An inflammatory process is implicated in the pathophysiology of MDD

The biomarker approach was developed by the GH-2000 group, a multi-center team led by Peter Sonksen at the appointment of the International Olympic Committee (IOC) [101]

Notably, one promising avenue involves leveraging the astrocytic urea cycle to enhance neuroprotection and facilitate a liver-like clearance mechanism in the brain, offering potential strategies for mitigating neurodegenerative processes 59,73

Published research/clinical protocols have reported daily dosing ranges such as
