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ROS include radicals, ions, or molecules that have an unpaired electron in the valence electron shell, including superoxide, hydroxyl radicals, hydrogen peroxide, peroxyl radicals, and other highly reactive species (18)

408,409,410 For patients with BRAF -mutant melanoma receiving MAPK inhibition-targeted therapy, drug resistance would inevitably occur within 612 months, which significantly hinders the treatment efficacy and result in frequent recurrence

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