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inhibition has been shown to reduce adipose mass in diet-induced obese mice

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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

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ClinicalTrials.gov no completed 5-Amino-1MQ human efficacy trial (evidence-gap note)

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