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The mechanisms of AFB1-induced toxicity are connected to the generation of excess reactive oxygen species (ROS), upregulation of CYP450 activities, oxidative stress, lipid peroxidation, apoptosis, mitochondrial dysfunction, autophagy, necrosis, and inflammatory response

A per discharge limit (the target amount, as defined in 413.40(a) of the regulations) is set for each hospital, based on the hospital's own cost experience in its base year, and updated annually by a rate-of-increase percentage specified in 413.40(c)(3)

By contrast, in GSH-depleted cells with BSO, a significant potentiation of the tBuOOH-evoked [Ca 2+ ] i increase was observed (Figures 3A,C)

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