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Debt securities are subject to credit risk and interest rate risk, and high-yield securities and unrated securities of similar credit quality have a much greater risk of default and their values tend to be more volatile than higher-rated securities with similar maturities

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Infection 17(4):245246

A lower sticker price from a supplier that fails on any of these isn't a saving it's an unverified blend feeding into sensitive metabolic readouts
Lastly, the AVONEX trial was the first study to report a treatment impact of any MS DMT on cognitive function
