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Although recurrent and metastatic tumors disappeared or diminished in size by radiation, tumors increased in size thereafter, despite additional adjuvant chemotherapy

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Melissa Morello, MD, fellow in adult congenital heart disease

But when they tried to administer it directly, they hit a fundamental problem: -MSH degrades within minutes in the bloodstream, making it impractical as a therapeutic agent

Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66