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In addition, the oldest orphan nuclear receptor estrogen-related receptor (ERR), an important regulator of metabolic gene transcription and innate immune function, including those induced by toll-like receptor (TLR) and antimicrobial activities against intracellular bacterial infection [147], facilitated post-translational activation of autophagy by deacetylating various autophagy-related proteins, including ATG5, BECN1, and ATG7

doi: 10.1021/acs.est.0c05931

2.3 ROS-responsive small molecule prodrugs Malignant tumors exhibit elevated levels of ROS due to altered metabolism and signaling pathways (Trachootham et al., 2009