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doi: 10.1038/nrn2995 174 NieH

(181) conducted a study involving 15 postmenopausal women with moderate OSAHS, administering estrogen (either oral CEE at 0.625 mg/d, estradiol valerate at 1 mg/d, or transdermal estradiol at 8 mg/week) in conjunction with combined progesterone (MPA at 2.510 mg/d) over a period of 50 days, and found no significant reduction in sleep-disordered breathing events

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