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Although one of these sites is located in the 5 promoter region and the other site in the 3 flanking region, both sites are functional, as they have both been shown to bind the PU.1 nuclear factor in gel mobility shift assays, and both mediate transcription, as assessed by reporter gene assays

The primary source of data was the PubMed database, accessing articles published between January 1980 and May 2025