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Description
NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor

doi:10.1093/ajcn/80.6.1551 Funk RS, Jones J, Polireddy K, et al
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As a molecule naturally occurring in the human body declining with age rather than foreign to our biology it rarely produces adverse reactions at the concentrations used in cosmetic formulations
