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4 Current status of GPx4 drug development In recent years, with the continuous deepening of the research on ferroptosis mechanism, targeting GPx4, as the core protein of ferroptosis regulation, has become a highly promising therapeutic strategy

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c-h , IP1 levels, indicating Gq/11 activation, measured in mouse melanoma cell lines after 10 nM GRP stimulation, with or without treatment with the GRPR inhibitor RC-3095 ( c-h ) or pre-treatment with the ER inhibitor ICI-182,780 ( c-f )

significantly lower than controls at 6 h), all metabolized glucose (Supplementary Fig
