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Elevated cytokines in the brain of those with Parkinson's disease is a consequence of neurodegeneration

ACS Omega 9 (19), 2067020701

Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects

Regulatory Mechanism of EAAC1 Expression in Neurons While GLAST and GLT-1 are constitutively expressed on the cell membrane of glial cells, the membrane expression levels of EAAC1 are approximately 20% of the total under normal conditions, while protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) activations increase the EAAC1 expression on the plasma membrane [56] (Figure 3)

However, excessive excitatory action of glutamate may cause excitotoxic neuronal damage as a result of a sustained influx of extracellular calcium ions (Ca 2+ ) [109, 110]