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Description
Mechanism of the Michael Reaction The Michael reaction involves just three key steps: deprotonation of the starting material to give an enolate conjugate addition (1,4-addition) of the enolate to an electrophilic alkene, and protonation of the resulting enolate Lets look at the first step with a malonic ester like in the first example of this article

10.1016/j.ccm.2020.05.002 2

10.1093/oxfordjournals.aob.a084729 Ann

Free Radic Biol Med (2015) 84:22745

Projections from the cortex, limbic system and hypothalamus to the A2 cell group region provide a route through which emotional and cognitive events can modulate visceral responses to diverse threats [10]
