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There were seven metabolic pathways screened including Phenylalanine, tyrosine and tryptophan biosynthesis, Glutathione metabolism, Phenylalanine metabolism, Lysine degradation, Cysteine and methionine metabolism, Tyrosine metabolism, and Tryptophan metabolism (Tables 3, 4)

The time intervals for the study were as follows: 0.5hr, lhr, 2hr, 4hr, 6hr, 8hr, lOhr, l2hr, 24hr after application of a patch