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Description
Lastly, in vitro studies showed that healthy neurons co-cultured with microglia from injured NOX2 KO mice were healthier, displayed less neuronal apoptosis, and cytotoxicity compared to neurons co-cultures with microglia from injured wild-type mice

AGER1 binds and degrades AGEs while RAGE promotes oxidative stress and has a freer rein in chronic diabetes since AGER1 removal of AGE is suppressed (138)

Glycation, a biochemical reaction where sugars bind non-enzymatically to proteins, lipids, or nucleic acids, results in the formation of Advanced Glycation End products (AGEs)

Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations

PMID 26431397