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Its ability to preserve mitochondrial integrity, enhance cerebral perfusion, mitigate oxidative stress, and support synaptic plasticity positions it as a neuroprotective adjunct rather than a primary monoaminergic antidepressant

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Beyond IL-1, gene therapies aiming to modulate inflammatory signalling pathways, such as NF-B or NLRP3 inflammasome inhibition, are being investigated to provide more durable cardioprotection [31]

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