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Cell 127, 397408

A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn's disease

The literature suggests that direct agonism of A1/A2 receptors by CBD is unlikely due to its concentrationeffect (E/c) curve and surplus agonist concentration, and, as such, indirect elevation of local adenosine levels is not only more plausible, but could represent a viable mechanism underlying CBDs actions through those receptors [73,77,78,79]

(Amsterdam: Elsevier)

Funding This work was supported by National Institutes of Health (CA230202 MS-L), O'Neal Comprehensive Cancer Center (IMPACT Award MS-L)