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Molecular mechanisms and clinical applications of angiogenesis

In addition, the inner-mitochondrial-membrane enzyme dihydroorotate dehydrogenase (DHODH) transfers electrons derived from pyrimidine synthesis to ubiquinone, reducing it to ubiquinol and thereby suppressing ferroptosis in parallel with mitochondrial GPX4 (Mao et al., 2021)

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Side effects of tirzepatide with B12 and management strategies Gastrointestinal side effects dominate the adverse event profile

For instance, recent studies show that the epigenetic and post-translational mechanisms tightly regulate ferroptosis in other tissues, while their specific roles in ocular cells remain largely unexplored, leaving a critical knowledge gap and hindering the identification of novel regulatory targets (152, 153)