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Intestinal permeability using sugar excretion tests (102) and 51 Cr-EDTA (103) started to be used in the eighties mainly with small groups of patients
Katz JN, Arant KR, Loeser RF
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Nutrients 8(12): 767
Although increasing the cohort size above six results in little increase in the probability of observing a given event, the higher the sample size the greater the probability for observing an event that is not due to a study drug but is simply part of the spontaneous event rate for that event
