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Prevention of Complications of Diabetic Neuropathy Diabetic Foot Ulcers DFUs are a serious complication of diabetic neuropathy

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Although, several studies have reported beneficial effects of capsaicin in various autoimmune diseases (reviewed in (88)), its effects on DCs remained controversial and its immunomodulatory mechanisms are not completely elucidated

19 Gene expression differences involved in O-GlcNAcylation and hexosamine biosynthesis pathway have also been detected between diabetic and nondiabetic individuals, 20 probably because multiple molecules in insulin signaling pathways can be modified by glycosylation which in turn reduces phosphorylation, leading to inhibition of insulin signaling

But there are no human psoriasis trials, so it remains experimental and is not a substitute for proven care