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JCI Insight 1 , e89790 (2016)

Antioxidant Protection : Acting as a powerful antioxidant, Vitamin C neutralizes free radicals produced by UV exposure and environmental stressors, helping to minimize premature skin aging

Prevalence: 400 million worldwide [1] Affects primarily males of African, Mediterranean, and Asian descent [2] Epidemiological data refers to the US, unless otherwise specified

This reinforces the need for carefully titrated regimens, especially in clinical settings where circadian timing (chronopharmacology) may dictate efficacy

Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide