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glutathione adduct of diclofenac DETECTION A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES Diclofenac Biodegradation by Microorganisms and

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Recent research has shown that the GLUD1 inhibitor purpurogallin analog R162 may have inhibitory effects on the growth of glioblastoma, non-small cell lung cancer, and breast cancer cells in vitro and in animal models [111]

glutathione adduct of diclofenac DETECTION A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES Diclofenac Biodegradation by Microorganisms and

Xue D, Zhou X, Qiu J

glutathione adduct of diclofenac DETECTION A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES Diclofenac Biodegradation by Microorganisms and

M.El GelanyS

glutathione adduct of diclofenac DETECTION A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES Diclofenac Biodegradation by Microorganisms and

These metals can interfere with enzymatic processes critical for detoxification and methylation

glutathione adduct of diclofenac DETECTION A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES Diclofenac Biodegradation by Microorganisms and

Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals

glutathione adduct of diclofenac DETECTION A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES Diclofenac Biodegradation by Microorganisms and

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