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Among circulating protein biomarkers, growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21), both upregulated by the mitochondrial integrated stress response, have demonstrated a robust diagnostic performance for mitochondrial myopathies, with additional promise as longitudinal indicators of treatment efficacy

In contrast, animals on a normal diet developed liver injury after APAP or allyl alcohol in the absence of relevant LPO [6769], and vitamin E treatment did not protect [67]

Retinoids inhibit measles virus through a type I IFN-dependent bystander effect

Symptoms of major depressive disorder include, but are not limited to, depressed mood, anhedonia, weight changes, sleep disturbances, worthlessness, and suicidal thoughts [19]

& Whalen, M