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Similar to the in vitro experiments, NAC primarily influences osteogenic effects through ROS and related redox signaling pathways in animal models

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Both trials (study design below), each with ~1840 participants, are expected to be completed (104-week treatment, and there is a 52-week extension) this September with announcement of the results soon thereafter

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Journal of Agricultural and Food Chemistry, 56: 954963

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d , Representative FLIM images of polyGA inclusions in HEK293T cells expressing polyGA-SNAP at the indicated time points, labelled with 1 M S-SBD-SNAP

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