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Liver cirrhosis, particularly when decompensated, associates with systemic inflammation and disturbed redox state,72,73 and hence associates with an increase in oxidized albumin forms HNA-1 and -2.11,13,14,74 Different groups found up to 50% increase in the proportion of HNA-1 and 200% of HNA-2 in patients with liver cirrhosis as compared with control healthy subjects.11,13,14,75 An increase in the percentage of oxidized albumin associated with severity of liver cirrhosis (as assessed by Child-Pugh-Turcotte class and MELD) and clinical decompensation such as development of ascites, HRS and bacterial infection.11,14,76 Finally, oxidized albumin correlated with short and long-term mortality in patients with liver cirrhosis, outperforming conventional prognostic tools such as MELD.11,75,76 Oettl, et al

Studies have shown that high doses of PPR (e.g., 10 mg/kg) significantly reduce sperm motility, concentration, and viability in adult male rats, with adverse effects on key reproductive markers and antioxidant enzymes (70, 71)

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On the basis of this evidence, a recent study showed that 12 weeks of supplementation with curcumin improved endothelial function in resistant arteries of healthy middle-aged and older adults

In ClinVar [3], the majority of interpreted missense variants are annotated as variants of uncertain significance (VUS) [4, 5]