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For instance, PhiKan083 and PK7088 specifically target the mutant p53 Y220C protein by stabilising its structure, thereby increasing the levels of p53 Y220C proteins with WT conformation and activity [209, 210]

These parameters act through distinct yet interconnected pathways to disrupt the delicate orchestration of the circadian system, with downstream consequences for reproductive endocrinology (Figure 3)

Thiopurine drugs have a relatively narrow therapeutic index and are capable of causing lifethreatening toxicity, most often myelosuppression (Sahasranaman et al., 2008)