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Description
There is at present no standard definition for this condition, nor consensus regarding its management, recommended therapy or the treatment period required [4]

N-to-B delivery can be a convenient method for rapidly targeting the CNS, bypassing the BBB, and minimizing systemic exposure

For the volumes used in peptide research (typically 0.05 to 0.5 mL), this is rarely an issue

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Rimbara, E., Mori, S., Kim, H