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In addition, patients with MS showed lowered expression of this vital antioxidant enzyme [6]

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It alleviates hepatic injury by activating the Nrf2/HO-1 antioxidant pathway and suppressing NF-Bmediated inflammation, highlighting its potential as a therapeutic applicant for ALD (94)

Immunosuppressive cells also express arginase 1 (ARG1) and indoleamine 2,3-dioxygenase (IDO) which deplete levels of L-arginine and tryptophan, respectively, from the microenvironment and thus suppress the functions of effector immune cells [92] (Fig