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P53 regulates redox balance by downregulating SLC7A11 to reduce cysteine and GSH levels, increasing ROS, and upregulating ALOX15 via SAT1 to enhance lipid peroxide production (Kang et al
After 8 weeks, the rats showed manifestations such as dull hair and irritability, an increased liver index, diffuse fatty hepatocytes, varying degrees of macrovesicular and microvesicular steatosis and occasionally inflammatory cell infiltration

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