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The bidirectional relationship between cancer epigenetics and metabolism

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It is however clear that whilst many non-surgical treatment modalities have emerged, there is still a lack of good quality, randomised data for the majority of these, requiring more investigation to identify the best modality and patient cohort for utilisation

Additionally, sex-specific cohort analysis indicates that smoking nearly doubles the risk of mortality in MASLD patients, especially in women, highlighting the importance of smoking cessation as a critical intervention in disease management [299]

In a model of lung injury induced by amethopterin, carnitine has shown therapeutic potential by reducing the activities of P53 and CD68 while increasing the activity of Bcl-2 [310]