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RotroffDCorumDMotsinger-ReifAFiehnOBottrelNDrevetsWet alMetabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: New mechanistic insights for rapid acting antidepressants

found that rotenone (a respiratory chain inhibitor that can increase mitochondrial ROS and total ROS) induced higher inflammasome activity of NLRP3 compared with lipopolysaccharide, indicating that ROS promoted the initiation step of NLRP3 assembly, and Nrf2 activation-induced NQO1 expression to clear ROS, thus inhibiting NLRP3 expression and subsequent caspase-1 cleavage ( Figure 5 ) (82)

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MyD88, myeloid differentiation factor 88

Selected Publications Veliz EA, Martnez-Hidalgo P, Hirsch AM., "Chitinase-producing organisms and their role in biocontrol", AIMS Microbiology 3 (3): 689-705 (2019)