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In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]

doi: 10.1210/jcem.77.2.8393882 91 Flechtner-MorsMJenkinsonCPAltABiesalskiHKAdlerGDitschuneitHH

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For the targeted acquisition of MS/MS spectra (parallel reaction monitoring) for the ubiquitin chainderived signature peptides, the Orbitrap Fusion LUMOS instrument was operated in targeted MS/MS mode using the Xcalibur software

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