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The epithelial component consists of basaloid matrical and supramatrical cells, which are mild to moderately pleomorphic and mitotically active.3 Small aggregates of eosinophilic shadow cells can also be present.4 Dendritic melanocytes without atypia are scattered among epithelial cells and show strong pigmentation.3 The epithelial component shows positivity for cytokeratin and beta-catenin, whereas dendritic melanocytes are highlighted by HMB-45, S-100 and Melan-A.3 Cases with atypical histologic features have been reported, such as melanocytic atypia, epidermal connection, calcification, granulomatous inflammation, epidermal consumption, or cystic degeneration.14 None of these features were present in the present case

Jet lag: therapeutic use of melatonin and possible application of melatonin analogs

doi: 10.1210/jc.2011-1408

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Kraft M, Kraft K, Grtner S, Mayerle J, Simon P, Weber E et al (2012) L-Carnitine-supplementation in advanced pancreatic cancer CARPANa randomized multicentre trial