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The architecture provides a predictive framework for how stress-induced CNS perturbations propagate to airway pathology, identifying intervention targets while flagging needs for further mechanistic validation

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Importantly, the potential for intercellular transport of large structures has been previously demonstrated for mitochondria and ribosomes 88,89,90,91

Additionally, it is not well defined whether disturbances in the transsulfuration pathway contribute to reduced GSH levels in PD contexts

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