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doi:10.1007/s00394-019-01993-8 Jayedi A, Zargar MS
The use of the patients own plasma helps in dealing with musculoskeletal issues effectively

Nicotinamide N-methyltransferase: a novel therapeutic target

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The study found that while low to moderate doses (2.5-250 g) provided some benefit, daily doses of around 500 g or more were required to restore healthy B12 levels
