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2.3 Role of mitochondria in disease progression Disease progression is a central theme in human pathology and is the overwhelming determinant in the morbidity and mortality associated with all diseases, especially those associated with chronic inflammation

Johns Wort and PPR, for example, induce CYP3A4 and P-gp, increasing the clearance of oral contraceptives, antivirals, and immunosuppressants (84)

Sometimes even a well-balanced diet cannot overcome the vitamin-depleting effects of medication

Hence easily precipitated

Variant genotypes of the GSTP1 Ile105Val gene polymorphism may contribute to the risk of chronic myelogenous leukemia (137-139)