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doi: 10.1136/annrheumdis-2019-215533 12 ArvanitiPZachouKLyberopoulouAGatselisNKBrooksWHDalekosGNet al

Usually, the HE syndrome produces neuropsychiatric symptoms which manifest themselves from mild to severe, with coma as the ultimate sequelae

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 1999

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